当前位置:成果展示 > 成果检索

Recombinant expression library of Pyrococcus furiosus constructed by high-throughput cloning: a useful tool for functional and structural genomics

[期刊论文] Frontier in Microbiology

Hyperthermophile Pyrococcus furiosus grows optimally near 100 degrees C and is an important resource of many i......

  • 关键词:
  • ligation-independent cloning; Pyrococcus futiosus; recombinant expression library; high-throughput cloning; phosphorothioate modification

pH-dependent recognition of apoptotic and necrotic cells by the human dendritic cell receptor DEC205

[期刊论文] PNAS

Dendritic cells play important roles in regulating innate and adaptive immune responses. DEC205 (CD205) is one......

  • 关键词:
  • DEC205; pH dependence; apoptosis; cryoEM; mannose receptor family

Acidic phospholipids govern the enhanced activation of IgG-B cell receptor.

[期刊论文] Nat Commun

B cells that express the isotype-switched IgG-B cell receptor (IgG-BCR) are one of the driving forces for anti......

  • 关键词:

Molecular Basis of MgATP Selectivity of the Mitochondrial SCaMC Carrier

[期刊论文] Structure

The mitochondrial matrix is the supplier of cellular ATP. The short Ca2+-binding mitochondrial carrier (SCaMC)......

  • 关键词:

Substrate-modulated ADP/ATP-transporter dynamics revealed by NMR relaxation dispersion.

[期刊论文] Nat Struct Mol Biol

The ADP/ATP carrier (AAC) transports ADP and ATP across the inner mitochondrial membrane. Unlike most transpor......

  • 关键词:

Structure of a yeast spliceosome at 3.6-angstrom resolution

[期刊论文] Science

Splicing of precursor messenger RNA (pre-mRNA) in yeast is executed by the spliceosome, which consists of five......

  • 关键词:

Cleavage of amyloid precursor protein by an archaeal presenilin homologue PSH

[期刊论文] PNAS

Aberrant cleavage of amyloid precursor protein (APP) by gamma-secretase contributes to the development of Alzh......

  • 关键词:
  • intramembrane protease; Alzheimer's disease; PSH; gamma-secretase; beta-amyloid peptide

The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6

[期刊论文] Nature immunology

Immune responses need to be tightly controlled to avoid excessive inflammation and prevent unwanted host damag......

  • 关键词:

Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus

[期刊论文] GENES & DEVELOPMENT

In many cells, mRNAs containing inverted repeated Alu elements (IRAlus) in their 3' untranslated regions (UTRs......

  • 关键词:
  • paraspeckles; p54(nrb); nuclear retention; CARM1; NEAT1

An iridium(III)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent

[期刊论文] The EMBO Journal

Bromodomain-containing protein 4 (BRD4) has recently emerged as an attractive epigenetic target for anticancer......

  • 关键词:

The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa

[期刊论文] Molecular Microbiology

Rhamnolipid acts as a virulence factor during Pseudomonas aeruginosa infection. Here, we show that deletion of......

  • 关键词:

Uncovering the Formation and Selection of Benzylmalonyl-CoA from the Biosynthesis of Splenocin and Enterocin Reveals a Versatile Way to Introduce Amino Acids into Polyketide Carbon Scaffolds

[期刊论文] JACS

Selective modification of carbon scaffolds via biosynthetic engineering is important for polyketide structural......

  • 关键词:
共8页  上一页下一页  转到第