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Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses

  • [设施]:上海光源
  • [期刊/会议名称]:science,342(6155):243-7(2013-10-11)
  • [摘要]:An avian-origin human-infecting influenza (H7N9) virus was recently identified in China. We have evaluated the viral hemagglutinin (HA) receptor-binding properties of two human H7N9 isolates, A/Shanghai/1/2013 (SH-H7N9) (containing the avian-signature residue Gln(226)) and A/Anhui/1/2013 (AH-H7N9) (containing the mammalian-signature residue Leu(226)). We found that SH-H7N9 HA preferentially binds the avian receptor analog, whereas AH-H7N9 HA binds both avian and human receptor analogs. Furthermore, an AH-H7N9 mutant HA (Leu(226) -> Gln) was found to exhibit dual receptor-binding property, indicating that other amino acid substitutions contribute to the receptor-binding switch. The structures of SH-H7N9 HA, AH-H7N9 HA, and its mutant in complex with either avian or human receptor analogs show how AH-H7N9 can bind human receptors while still retaining the avian receptor-binding property.
  • [发表日期]:2013
  • [第一作者]:Shi, Y
  • [第一作者单位]:中科院微生物所
  • [通讯作者]:高福
  • [通讯作者单位]:中科院微生物所
  • [论文类型]:期刊
  • [期刊分类]:SCI1区
  • [学科分类]:生物学_ 生物化学
  • [影响因子]:
  • [关键词]:A VIRUS; CONFORMATIONAL-ANALYSIS; HUMAN CONJUNCTIVITIS; TRANSMISSION; SPECIFICITY; ORIGIN; SIALYLOLIGOSACCHARIDES; COMPLEXES; SELECTION; OUTBREAK
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  • [简介]:随着交通运输水平的提高,流动人口的增加,由各种病原体引起的能在人与人、动物与动物或人与动物之间相互传播的一类疾病的防治与研究显的尤为重要。2013年,中国科学院北京生命科学研究院/微生物研究所高福课题组利用上海光源生物大分子晶体学光束线站(BL17U1),在高致病性禽流感感染人传播机制及跨种传播机制和新冠状病毒侵入宿主细胞机制研究等方面开展研究,取得重要进展。