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Structural Basis for the Selective Pb(II) Recognition of Metalloregulatory Protein PbrR691

  • [设施]:上海设施
  • [期刊/会议名称]:Inorganic Chemistry
  • [摘要]:The transcription regulator PbrR691, one of the MerR family proteins, shows extremely high sensitivity and selectivity toward Pb(II) in Ralstonia metallidurans CH34. Here, we present the crystal structure of PbrR691 in complex with Pb(II) at 2.0 Å resolution. The Pb(II) coordinates with three conserved cysteines and adopts a unique trigonal-pyramidal (hemidirected) geometry. To our knowledge, the PbrR691-Pb(II) structure provides the first three-dimensional visualization of a functional hemidirected lead(II) thiolate coordinate geometry in a protein.
  • [发表日期]:2016
  • [第一作者]:Shanqing Huang
  • [第一作者单位]:Coordination Chemistry Institute and the State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University
  • [通讯作者]:Hao Chen
  • [通讯作者单位]:Coordination Chemistry Institute and the State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University
  • [论文类型]:0
  • [期刊分类]:SCI2区
  • [学科分类]:化学
  • [影响因子]:4.857
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