1. 登录 | 注册 | 用户中心 | 关于平台 | 中国科学院
当前位置:成果展示 > 成果详情

Crystal structure of the sensor domain of BaeS from Serratia marcescens FS14.

  • [设施]:上海光源
  • [期刊/会议名称]:Proteins
  • [摘要]:The sensor histidine kinases of two-component signal-transduction systems (TCSs) are essential for bacteria to adapt to variable environmental conditions. The two-component regulatory system BaeS/R increases multidrug and metal resistance in Salmonella and Escherichia coli. In this study, we report the X-ray structure of the periplasmic sensor domain of BaeS from Serratia marcescens FS14. The BaeS sensor domain (34-160) adopts a mixed α/β-fold containing a central four-stranded antiparallel β-sheet flanked by a long N-terminal α-helix and additional loops and a short C-terminal α-helix on each side. Structural comparisons revealed that it belongs to the PDC family with a remarkable difference in the orientation of the helix α2. In the BaeS sensor domain, this helix is situated perpendicular to the long helix α1 and holds helix α1 in the middle with the beta sheet, whereas in other PDC domains, helix α2 is parallel to helix α1. Because the helices α1 and α2 is involved in the dimeric interface, this difference implies that BaeS uses a different dimeric interface compared with other PDC domains
  • [发表日期]:2017
  • [第一作者]:张亚
  • [第一作者单位]:南京农业大学
  • [通讯作者]:冉婷婷, 王伟武
  • [通讯作者单位]:南京农业大学
  • [论文类型]:0
  • [期刊分类]:SCI3区
  • [学科分类]:生物学_ 生物化学
  • [影响因子]:2.289
  • [关键词]:
  • [卷号]:
  • [期号]:
  • [起止页码]:
  • [简介]: