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Chemical antagonism between photodynamic agents and chemotherapeutics: mechanism and avoidance

  • [设施]:上海设施
  • [期刊/会议名称]:CHEM COMMUN
  • [摘要]:We report a photochemical reaction-induced antagonism between the photodynamic agent (PS) and anti-cancer drugs during combined therapy. The annihilation of singlet oxygen and alkene-containing drugs into inactive drug hydroperoxides is responsible for the antagonism, and results in decreased efficacy against several cancer cell lines. Experimental and simulation results reveal that the annihilation abates with increasing distance between the PS and drugs via confining the PS and drugs into separated vehicles. As a result, antagonism can be switched to synergism in treating both drug sensitive and resistant cancer cells
  • [发表日期]:2017
  • [第一作者]:Qingshuo Meng,Jia Meng
  • [第一作者单位]:State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China;University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China
  • [通讯作者]:Dr. Pengcheng Zhang,Prof. Yaping Li
  • [通讯作者单位]:State Key Laboratory of Drug Research & Center of Pharmaceutics, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, China;University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China
  • [论文类型]:期刊
  • [期刊分类]:SCI1区
  • [学科分类]:生物学_ 生物化学
  • [影响因子]:6.319
  • [关键词]:NANOPARTICLES, CISPLATIN, CONVERSION, COMBINATION THERAPY, RESISTANT TUMOR, SINGLET OXYGEN, CANCER, LIPOSOMES, CELL, CHEMISTRY, MULTIDISCIPLINARY, TRIGGERED DRUG-RELEASE, Drugs, Singlet oxygen, Photochemical reactions, Alkenes, Confining, Cancer, Anticancer properties
  • [卷号]:53
  • [期号]:92
  • [起止页码]:12438-12441
  • [简介]: