National Facility for Protein Science in Shanghai, located in the Pudong New Area of Shanghai, operates under the host institution of the Shanghai Advanced Research Institute (SARI). Having passed national acceptance in July 2015, the facility houses the China Structural Biology Database and possesses integrated capabilities for high-throughput, high-precision, and large-scale protein preparation, structural analysis, and functional research. Characterized by its integration, high-throughput capacity, and digitalization, the facility provides robust support for cutting-edge protein science research and drives advancements in industries such as biomedicine and modern agriculture.