Embryonic stem cells (ESCs) possess the capacity for self-renewal and multilineage differentiation, along with high genome stability. Maintaining high-level ribosome biogenesis is essential for ESCs to sustain their identity, and this process begins with RNA polymerase I-mediated transcription of ribosomal RNA (rRNA) genes.In ESCs, rDNA loci exhibit a hyperactive chromatin state, characterized ...

A research team from the Kunming Institute of Zoology (KIZ) of the Chinese Academy of Sciences has demonstrated for the first time in non-human primates that auditory stimulation at 40-Hz significantly elevates β-amyloid levels in the cerebrospinal fluid (CSF) of aged rhesus monkeys, with this effect persisting for over five weeks.The study, published in PNAS on January 5, provides the first n...

June 11, 2025The Primate Phenotype and Genetics Research Facility (Primate Facility) at the Kunming Institute of Zoology (KIZ), Chinese Academy of Sciences (CAS), hosted its 5th 2025 User Symposium. Attendees included Dr. Li Yingji, General Manager of Beijing ICROVIS Biotechnology Co., Ltd., and Professor Niu Haichen, General Manager of Xuzhou Zhongshu Biotechnology.Dr. Li delivered a keynote t...

On May 29, Professor Mohammad Javan, Director of the Primate Advanced Research Center of Excellence (PARCE) at the Royan Institute for Reproductive Biomedicine (Iran), led a delegation to visit the Kunming Institute of Zoology (KIZ), Chinese Academy of Sciences (CAS). The delegation included Dr. Mohammad Reza Abolghasemi, Deputy Director of PARCE, and Dr. Mostafa Hajinasrollah.The delegation to...

On May 16, the National Facility for Phenotypic and Genetic Analysis of Model Animals (Primate Facility) at KIZ held its fourth user academic exchange meeting of 2025, focusing on Neural Modulation. The meeting was chaired by Professor Yonggang Yao, a researcher at KIZ and Director of the Primate Facility. Invited keynote speakers included Researcher Zhihai Qiu and Researcher Xinyi Lai from the...

On April 28, the National Primate Facility held its third user academic exchange meeting of 2025. The meeting was co-chaired by Researcher Bingyu Mao (KIZ), Professor Ke Ma (Xinhua Hospital), and Professor Youqing Huang (Kunming Medical University). Six experts delivered reports on neurological disease mechanisms, neural modulation, brain-computer interfaces, biomaterials, and analgesic drug de...

On April 23, the National Primate Facility held its second 2025 user academic exchange at KIZ, focusing on Cell Therapy. Chaired by Researcher Dengfeng Zhang, Professor Bo Peng (Fudan University)presented "Microglia Turnover and Replacement – From Basic Research to Clinical Therapy."Professor Peng shared breakthroughs in microglia dynamics during aging/disease and novel intervention strategie...

On April 2, KIZ and Shanghai Jiao Tong University (SJTU) signed a cooperation framework agreement in Shanghai. Signatories included Director Peng Shi (KIZ) and Vice President Zhaoguo Zhang (SJTU). Attendees included Academician Chunhai Fan (SJTU) and Deputy Director Dongdong Wu (KIZ).The agreement enhances collaboration in academic exchange, interdisciplinary research, and clinical translation ...

On February 8,the Primate Facility convened its second Science and Technology Committee meeting and 2025 Operation Plan review. Committee Chair Lin Li (Academician) and KIZ Deputy Director Bingyu Mao co-chaired the hybrid session.KIZ Director Yonggang Yao reported on 2024 trial operations and the 2025 plan. The committee affirmed the facility’s scientific vision,recognized progress in technolo...

January 3–4, 2025KIZ hosted the "Brain Disease Basic-Clinical Integration Symposium" to foster cross-disciplinary collaboration. Co-organized by KIZ’s State Key Laboratory of Genetic Resources and Evolution, Primate Facility, Yunnan Key Laboratory of Animal Models, and CAS Youth Innovation Promotion Association, the event featured 13 young scholars from global institutions.KIZ Director and Pr...